|
Dosage
Starting dose
|
| bet | 591/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Dosage
|
Starting dose: 10 to 15 microgram/kg/dose DAILY.[2]
Maintenance dose: 8 to 10 microgram/kg/dose DAILY.
Severe congenital hypothyroidism [free T4 <5 pmol/L] –Start with highest initial dose.
Round dose to nearest half or whole tablet where possible, particularly for discharge eg 25 microgram or 50 microgram.
Refer to monitoring section for goals of therapy.
|
Route
|
PO
|
Maximum Daily Dose
|
|
Preparation
|
Oral compounded suspension is not advised. Tablet freshly dispersed in water immediately prior to administration is recommended. Dose to be rounded to the nearest half/whole tablet where possible and disperse/administer using method 1 or 2 below. Tablets can be difficult to quarter with a tablet cutter.
Method 3 is for preparing a 10 microgram/mL dispersion just prior to administration and should only be used for administering small doses where a tablet/tablet portion cannot be used. Method 3 is for inpatient use only.
Method 1 – round dose to the nearest half or whole tablet:
If required, halve tablet using a tablet cutter.
Use tablet crusher to crush tablet/tablet portion.
Add approximately 1 mL of water (sterile/freshly boiled and cooled) to powder in tablet crusher and mix well.
Draw up suspension in oral syringe/dispenser.
Rinse tablet cutter with a few drops of water and add to oral syringe/dispenser. Make sure as much as possible of the suspension is transferred to ensure an accurate dose.
|
|
| |
