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Neonatal Intensive Care Drug Manual
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| bet | 625/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Renal impairment
For infants with renal impairment, consider using antibiotic without nephrotoxicity in consultation with an infectious diseases specialist. If vancomycin is used, perform a trough concentration before the 2nd dose, irrespective of corrected gestational age.
Contraindications
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Known hypersensitivity to vancomycin.
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Precautions
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Use with caution in patients with renal impairment or those receiving other nephrotoxic, neurotoxic or ototoxic drugs.
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Drug interactions
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Neurotoxic and nephrotoxic drugs – concurrent use of these agents may contribute to the additive neurotoxic and nephrotoxic effects.
Diuretics – potent diuretics (e.g., furosemide) may add to the ototoxic effect.
Neuromuscular blocking agents (e.g. pancuronium, suxamethonium, vecuronium) – vancomycin may enhance neuromuscular blockade.
Vancomycin may be combined with an aminoglycoside, cephalosporin or rifampicin for synergistic activity.
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