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Neonatal Intensive Care Drug Manual
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| bet | 626/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Adverse reactions
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Infusion-related events: Rapid infusion may cause red man syndrome – a predominately histamine-mediated reaction with pruritus, tachycardia, hypotension and rash. It appears rapidly and usually dissipates in 30─60 minutes, but may persist for several hours. Increasing the infusion time usually eliminates the risk for subsequent doses.
Anaphylactic reactions may occur. Severe reactions may require treatment with adrenaline (epinephrine), corticosteroids or oxygen.
Phlebitis and tissue irritation and necrosis may occur, especially after extravasation. Intramuscular injection is not recommended.
Neurotoxicity, ototoxicity and nephrotoxicity ─ these are more pronounced with the addition of other medications such as aminoglycosides or furosemide.
Neutropenia and thrombocytopenia have been reported in adults. Risk is increased with prolonged therapy >1 week but they appear to be reversible when vancomycin is discontinued.
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Compatibility
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Fluids: Glucose 5%, glucose 10%, sodium chloride 0.9%.
Y site: amino acid solutions and fat emulsions, aciclovir, adrenaline (epinephrine) hydrochloride, amifostine, amiodarone, anidulafungin, atracurium, caspofungin, cisatracurium, dobutamine, dopamine, dexmedetomidine, esmolol, filgrastim, fluconazole, gentamicin, granisetron, hydromorphone, insulin regular, labetalol, linezolid, magnesium sulfate, meropenem, midazolam, milrinone, morphine sulfate, mycophenolate mofetil, noradrenaline (norepinephrine), palonosetron, pancuronium, pethidine, potassium chloride, remifentanil, tigecycline, vecuronium, zidovudine.
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Incompatibility
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Fluids: No information.
Y-site: albumin, aminophylline, azathioprine, beta-lactam antibiotics (eg. penicillins, cephalosporins), bivalirudin, calcium folinate, chloramphenicol, daptomycin, foscarnet, furosemide, ganciclovir, heparin sodium, indometacin, ketorolac, methylprednisolone sodium succinate, moxifloxacin, omeprazole, rocuronium, sodium bicarbonate, sodium valproate, streptokinase, urokinase.
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Stability
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Administer immediately, discard unused portion of reconstituted solution.
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