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Use in gastrointestinal bleeding
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| bet | 634/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Use in gastrointestinal bleeding: There are few reports of argipressin use for gastrointestinal bleeding in newborns. The dose regimen is unclear and other agents may be more effective.
Drug Interactions
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Noradrenaline (norepinephrine) and heparin—when used with argipressin may decrease the antidiuretic effect of argipressin.
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Adverse Reactions
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Causes water retention and hyponatraemia. Early or over vigorous administration may provoke cerebral oedema,
Cardiac complications include coronary ischaemia, myocardial infarction, ventricular arrhythmias (ventricular tachycardia and asystole) and severe hypertension. Other reported adverse effects include severe GI ischaemia leading to bowel necrosis, hyponatraemia, anaphylaxis, bronchospasm, urticaria, angioedema, rashes, venous thrombosis, local irritation at injection site and peripheral vasoconstriction leading to cutaneous gangrene.1,2
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Compatibility
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Fluids: Glucose 5%, sodium chloride 0.9%
Y-site: Amiodarone, pantoprazole (EDTA-free).
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Incompatibility
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Fluids: No information.
Y-site: Diazepam, furosemide (frusemide), indometacin, phenytoin.
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Stability
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Diluted solution: Discard remainder after use.
Change infusion solution every 24 hours
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Storage
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Ampoule: Store below 25°C.
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Special Comments
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Administration via a central line is preferred as extravasation may cause tissue necrosis.
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Evidence summary
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Efficacy:
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