Alert
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This formulary covers oral vitamin E.
Vitamin E 1 International Unit (hereafter referred to as “units” ) = 0.67 mg d-alpha-tocopherol.1
Penta-Vite, a commonly used multi-vitamin supplement doesn’t contain vitamin E.
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Indication
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Prevention and treatment of vitamin E deficiency.
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Action
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Fat soluble vitamin. It is an antioxidant protecting cell membranes from oxidative stress. Active isomer is α-tocopherol.
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Drug type
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Fat soluble vitamin.
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Trade name
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Micel-E oral liquid
Aqua-E oral liquid
Bio-Logical Vitamin A and E Solution
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Presentation
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Micel-E oral liquid: d-alpha-tocopherol 104.7 mg/mL (vitamin E 156 units/mL); 50 mL bottle.
Aqua-E 20IU/ml
Bio-Logical Vitamin A and E Solution- 1mL contains 2210 IU (663 microg) Vitamin A and 102 IU Vitamin E
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Dose
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Vitamin E supplementation in preterm neonates*
8 units/kg daily (6-12 IU/kg/day)2
15-25 units/kg/day for cholestasis
*Preterm human milk + Human milk fortifier (HMF) at 170 mL/kg/day provides an average 8 units/kg/day.
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Dose adjustment
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Therapeutic hypothermia – No information.
ECMO – No information.
Renal impairment – No information.
Hepatic impairment – No information.
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Maximum dose
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Doses exceeding 25 units/kg/day ORAL may pose more risk than benefit for preterm neonates.3
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Route
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Oral
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Preparation
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No preparation is required.
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Administration
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Administer undiluted.
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Monitoring
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Serum vitamin E levels – Not routinely required. Target 1.0-2.0 mg/dL.4,5
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