IM
prophylaxis
< 1500 g administer 0.5 mg (0.05 mL) as a single dose at birth.
≥ 1500 g administer 1 mg (0.1 mL) as a single dose at birth.
Oral prophylaxis
Administer 2 mg orally for 3 doses:
First dose: At birth.
Second dose: 3–5 days of age (at time of newborn screening) or at one week of age
Third dose: 4 weeks of age.
IV prophylaxis
Administer 0.3 mg/kg as a single dose. Administer slowly, not exceeding 1 mg/minute.
IV prophylaxis may be given in sick infants if unable to give by IM injection.
IV treatment of haemorrhagic disease of the newborn
Administer 1 mg IV as a slow bolus (maximum 1 mg per minute). If required, dilute with glucose 5% or sodium chloride 0.9% as described below.
Dose can be repeated in 4–6 hours if required.
Must be administered in the presence of a medical officer.
May be given subcutaneously if venous access not available.
| 