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Neonatal Intensive Care Drug Manual
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| bet | 645/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Preparation/Dilution
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IM and oral: Administer injection undiluted.
IV: If required draw up one ampoule (0.2 mL) and dilute up to 2 mL (to make a 1 mg/mL solution) with glucose 5% or sodium chloride 0.9%.
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Administration
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IV: Administer as a slow IV bolus. Maximum rate 1mg per minute. Administer undiluted or dilute with sodium chloride 0.9% or glucose 5% as above. May be injected into the lower part of an infusion set running sodium chloride 0.9% or glucose 5%.
IM: Administer undiluted. Do not use the solution if it is turbid or separated. Solution must be clear.
Oral: Injection solution can be administered orally. Break ampoule, place dispenser vertically into ampoule; withdraw solution from ampoule into dispenser until solution reaches marking on dispenser (2 mg); administer contents directly into mouth.
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Monitoring
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Monitor prothrombin time when treating clotting abnormalities (a minimum of 2 to 4 hours is needed for measurable improvement).
Efficacy of treatment with Vitamin K1 is decreased in patients with liver disease.
The risk of childhood cancer is not increased by IM administration of vitamin K1.
Repeated doses are advised if infant vomits within an hour of an oral dose or if diarrhoea occurs within 24 hours of administration. Check with medical officer for advice.
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