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Management of vitamin K deficiency bleeding
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| bet | 648/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Management of vitamin K deficiency bleeding: Administer Vitamin K1 (phytomenadione) 1 mg intravenously slowly (LOE IV, GOR B). Give subcutaneously if venous access not available.6
Pharmacokinetics: In healthy, fully breast-fed, newborn babies, significantly higher plasma vitamin K1 concentrations were reported several weeks after IM as compared to oral vitamin K1. Half-life of oral and intramuscular vitamin K1 were considerably longer in newborn infants (median 76 hours; range 26 to 193 hours) 7, 8 compared to adults (6 hours; range 2–26 hours)9. Re-dosing of oral vitamin K1 is recommended by 1 month in breast fed infants.8 (LOE II GOR B)
In preterm infants and sick infants unable to receive intramuscular vitamin K1, 0.3 mg/kg intravenously resulted in similar serum concentrations as oral administration of 3 mg vitamin K1 and after intramuscular administration of 1.5 mg vitamin K1. Supports recommendation for intravenous 0.4 mg/kg phytomenadione - vitamin K1 - Konakion MM Paediatric in infants unable to receive oral or intramuscular vitamin K1.7 (LOE IV, GOR B).
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