Neonatal Intensive Care Drug Manual

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Contraindications
Oral prophylaxis is contraindicated in infants who are: Premature; unwell; on antibiotics; have cholestasis; have diarrhoea. Oral prophylaxis is contraindicated in infants of mothers who are on anticonvulsants including phenytoin, barbiturates and carbamazepine; rifampicin and the vitamin K antagonists including warfarin and phenindione.
Precautions	IV administration is associated with a possible risk of kernicterus in premature infants weighing less than 2.5 kg.
Drug Interactions	Co-administration of anticonvulsants can impair the action of vitamin K₁.
Adverse Reactions	Pain, swelling and erythema at IM injection site. Severe hypersensitivity reactions, including death have been reported with rapid IV administration – administer IV doses slowly and only on recommendation by a consultant.
Compatibility	Fluids: Glucose 5%, glucose 10%, sodium chloride 0.9%. Y site: Alfentanil, amikacin, aminophylline, ascorbic acid, atracurium, atropine sulfate, aztreonam, calcium chloride, calcium gluconate, cefazolin, cefotaxime, ceftriaxone, dexamethasone, dopamine, adrenaline (epinephrine), fentanyl, furosemide (frusemide), gentamicin, heparin sodium, hydrocortisone, indomethacin, magnesium sulfate, midazolam, morphine, phenobarbital (phenobarbitone), sodium bicarbonate, vancomycin.

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