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Neonatal Intensive Care Drug Manual
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| bet | 652/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Zoster Immunoglobulin
Revision Date : 28/2/2021
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Approved: TC, KOH
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Indication :
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Prevention of Varicella infection in babies or young infants with family contacts recently developing chicken pox or shingles.
Post exposure prophylaxis for babies of mothers who have developed chicken pox from 7 days prior to 7 days after delivery.
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Dose :
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125 IU
62.5 IU in patients weighing less than 2 kg
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Interval :
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Once only, but the dose may be repeated if a second exposure occurs more than 3 weeks after the first dose.
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Route :
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I.M.
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Total Daily Dose :
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Comments :
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- Not useful in the management of established infection.
- ZIG must be given as early as possible in the incubation period within 96 hours of exposure if possible but may be given up to 10 days post exposure.
- Side effects include Injection site pain, fever, vomiting, rash, fatigue and sweating
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Supplied as :
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ZIG - CSL. Available from blood bank.
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Dilution :
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Nil.
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Stability :
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After reconstitution, may be stored for up to 12 hours under refrigeration.
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Storage :
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Refrigerate at 2 - 8oC. Do not freeze. Protect from light.
Bring to room temperature before deep intramuscular administration.
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Incompatibility :
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NA
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Serum Levels :
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NA
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References:
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1. Levin MJ, Duchon JM, Swamy GK, Gershon AA. Varicella zoster immune globulin (VARIZIG) administration up to 10 days after varicella exposure in pregnant women, immunocompromised participants, and infants: Varicella outcomes and safety results from a large, open-label, expanded-access program. PLoS One. 2019 Jul 3;14(7):e0217749. doi: 10.1371/journal.pone.0217749. PMID: 31269033; PMCID: PMC6608934.
2. Tebruegge M, Pantazidou A, Curtis N. Towards evidence based medicine for paediatricians. How effective is varicella-zoster immunoglobulin (VZIG) in preventing chickenpox in neonates following perinatal exposure? Arch Dis Child. 2009 Jul;94(7):559-61. doi: 10.1136/adc.2008.154542. PMID: 19542068.
3. South Australian Neonatal Medication Guidelines
4. UpToDate -Varicella-Zoster Immune Globulin (Human) Drug Information
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Original version Date: 2014
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Author: DD
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Current Version number: 2.0
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Version Date: 1/3/2021
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Risk Rating: Low
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Due for Review: 16/11/2026
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Approved by: DTC
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Approval Date: TBA
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