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Neonatal Intensive Care Drug Manual
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| bet | 630/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Prevention of infection: Systematic review of 2 RCTs found prophylactic systemic antibiotics in neonates with a central venous catheter reduces the rate of proven or suspected septicaemia. However, there was no significant difference in mortality, a lack of data on long-term neurodevelopmental outcome and of data pertaining to the potentially significant disadvantages of this approach such as the selection of resistant organisms. The routine use of prophylactic antibiotics in infants with central venous catheters in neonatal units cannot currently be recommended. [12] [LOE I GOR D] Three other RCTs have also reported similar effects of prophylactic vancomycin in infants with or without central lines.[13-15]
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