Use in pulmonary hypertension




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Sana03.01.2022
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Use in pulmonary hypertension: In a case series of 10 newborn infants with severe persistent pulmonary hypertension of the newborn on nitric oxide, argipressin 0.0002 ± 0.0002 U/kg/minute (0.012 ± 0.012 units/kg/hour) was associated with an improvement in oxygenation index, peak effect 6 hours after initiation, and a reduction in inhaled nitric oxide dose, improvement in blood pressure and urine output (p < 0.05), without drop in the serum sodium level or worsening in serum lactate level.6 The role of argipressin for pulmonary hypertension in newborns is unclear. (LOE IV, GOR D)


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