AAP Committee on fetus and newborn




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AAP Committee on fetus and newborn: Caffeine citrate is a safe and effective treatment of apnea of prematurity when administered at a 20-mg/kg loading dose and 5 to 10 mg/kg per day maintenance. Monitoring routine serum caffeine levels usually is not contributory to management. A trial off caffeine may be considered when an infant has been free of

clinically significant apnea/bradycardia events off positive pressure for 5 to 7 days or at 33 to 34 weeks’ PMA, whichever comes first. [2] However, caffeine may not reach subtherapeutic levels until 11-12 days post-cessation [6].




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