Reduce dose in hepatic and renal impairment.
Avoid prolonged use and abrupt withdrawal thereafter.
Administration with other CNS depressants such as opioids, benzodiazepines or barbiturates may produce excessive sedation.
Indirect hyperbilirubinaemia may occur after prolong use because TCE and bilirubin compete for hepatic conjugation.
Use cautiously in preterm infants because of the risk of respiratory depression.
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