Neonatal Intensive Care Drug Manual

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Dosage/Interval
Sedation for painless procedure: Term infants: 50 mg/kg/dose (25–75 mg/kg/dose). Preterm infants: 25 mg/kg/dose (25–75 mg/kg/dose). Give the dose 45 minutes before procedure. Repeated doses up to maximum of 100 mg/kg may be used with respiratory monitoring. Short-term sedation: 8 mg/kg/dose q6–8 hourly.
Route	Oral Note: Rectal administration is erratically absorbed and therefore not recommended.
Maximum Daily Dose	100 mg/kg
Preparation/Dilution	Syrup – 100 mg/mL (osmolality is 3285 mOsm/kg of water)
Administration	Oral preparation should be diluted 1:3 with water or administered after feeding to reduce gastric irritation.
Monitoring	Chloral hydrate is well tolerated by most patients with single dose or short-term use. Most common reported adverse effect is mild respiratory depression and bradycardia in former preterm infants.^1,2 Observe for respiratory depression, blood pressure and level of sedation.

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