Chloral hydrate may have an additive effect with opioids, barbiturates, benzodiazepines leading to respiratory depression.
Chloral hydrate may produce a transient increase in response to warfarin due to displacement of warfarin from its protein binding site.
Intravenous furosemide administration after chloral hydrate has been reported to produce diaphoresis, flushing, changes in blood pressure and tachycardia in adults and older children.
Chloral hydrate may displace phenytoin from protein binding sites and reduce its rate of elimination.
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