• Indication Treatment of acute bacterial conjunctivitis Action
  • Drug Type Broad spectrum antibiotic Trade Name
  • Presentation
  • Chloramphenicol (Topical)




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    Chloramphenicol (Topical)


    Revision Date : 21/06/2019

    Approved : TC, KOH




    Alert

    Eye ointment remains in the eye for longer than eye drops and may be the preferred dose form.

    Indication

    Treatment of acute bacterial conjunctivitis

    Action

    Bacteriostatic. Acts by inhibition of protein synthesis, interfering with the transfer of activated amino acids from soluble RNA to ribosomes.

    Drug Type

    Broad spectrum antibiotic

    Trade Name

    Chloromycetin, Chlorsig

    Presentation

    Chloramphenicol eye drops 0.5% contains 5 mg/mL, chloramphenicol eye ointment 1% contains 10mg/g

    Dosage/Interval


    Ointment:

    Apply 3 to 4 times a day in the affected eye and continue for 48 hours after clinical resolution.

    Severe infection: May need more often at the discretion of the treating team.

    DROPS:


    Severe infection: Apply 1 drop every 2 hours in the affected eye for 48 hours and reduce frequency with controlling of infection.

    Less severe infection: Apply 3 to 4 times a day in the affected eye

    Continue for 48 hours after clinical resolution
    Drops and Ointment combination:

    Apply drops during the day as above

    Apply ointment once at night

    Continue for 48 hours after clinical resolution.




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