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Neonatal Intensive Care Drug Manual
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| bet | 118/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Conclusion: Most children presenting with acute infective conjunctivitis in primary care will get better without topical antibiotic treatment. Moreover, failure of clinical cure is frequent with chloramphenicol. Treatment should be guided by microbiological testing including for chlamydia and gonococcus if clinically indicated or in areas of increased prevalence prior to initiation of eye drops.
References
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Robert PY, Adenis JP. Comparative review of topical ophthalmic antibacterial preparations. Drugs. 2001;61:175-85.
Sheikh A, Hurwitz B, van Schayck CP, McLean S, Nurmatov U. Antibiotics versus placebo for acute bacterial conjunctivitis. Cochrane database of systematic reviews (Online). 2012;9:CD001211.
Rose PW, Harnden A, Brueggemann AB, Perera R, Sheikh A, Crook D, Mant D. Chloramphenicol treatment for acute infective conjunctivitis in children in primary care: A randomised double-blind placebo-controlled trial. Lancet. 2005;366:37-43.
Fukuda M, Ohashi H, Matsumoto C, Mishima S, Shimomura Y. Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus ocular surface infection: Efficacy of chloramphenicol eye drops. Cornea. 2002;21:S86-S9.
Griffiths P. What type of eye drops should be given to a toddler with conjunctivitis? British journal of community nursing. 2003;8:364-8.
Horven I. Acute conjuctivitis. A comparison of fusidic acid viscous eye drops and chloramphenicol. Acta Ophthalmologica. 1993;71:165-8.
Hvidberg J. Fusidic acid in acute conjunctivitis. Single-blind, randomized comparison of fusidic acid and chloramphenicol viscous eye drops. Acta Ophthalmologica. 1987;65:43-7.
Normann EK, Bakken O, Peltola J, Andreasson B, Buhl S, Sigg P, Nielsen K. Treatment of acute neonatal bacterial conjunctivitis: A comparison of fucidic acid to chloramphenicol eye drops. Acta Ophthalmologica Scandinavica. 2002;80:183-7.
Dirdal M. Fucithalmic in acute conjunctivitis. Open, randomized comparison of fusidic acid, chloramphenicol and framycetin eye drops. Acta Ophthalmologica. 1987;65:129-33.
Van Bijsterveld OP, El Batawi Y, Sobhi FS, Nassar MW. Fusidic acid in infections of the external eye. Infection. 1987;15:16-9.
Laporte JR, Vidal X, Ballarin E, Ibanez L. Possible association between ocular chloramphenicol and aplastic anaemia - The absolute risk is very low. British Journal of Clinical Pharmacology. 1998;46:181-4.
Walker S, Diaper CJM, Bowman R, Sweeney G, Seal DV, Kirkness CM. Lack of evidence for systemic toxicity following topical chloramphenicol use. Eye. 1998;12:875-9.
Amichai B, Grunwald MH, Halevy S. Erythema multiforme resulting from chloramphenicol in eye drops: Confirmation by mast cell degranulation test. Annals of Ophthalmology - Glaucoma. 1998;30:225-7.
Doshi B, Sarkar S. Drug point: Topical administration of chloramphenicol can induce acute hepatitis. BMJ (Online). 2009;339:574.
Darling EK, McDonald H. A Meta-analysis of the Efficacy of Ocular Prophylactic Agents Used for the Prevention of Gonococcal and Chlamydial Ophthalmia Neonatorum. Journal of Midwifery and Women's Health. 2010;55:319-27.
Schofield CBS, Shanks RA. Gonococcal ophthalmia neonatoriun despite treatment with antibacterial eye drops. British Medical Journal. 1971;1:257-9.
Schofield CBS, Shanks RA. Gonococcal ophthalmia neonatorum despite treatment with antibacterial eye drops. Britmedj. 5743;1:484-90.
Ramirez-Ortiz MA, Rodriguez-Almaraz M, Ochoa-DiazLopez H, Diaz-Prieto P, Rodriguez-Suarez RS. Randomised equivalency trial comparing 2.5% povidone-iodine eye drops and ophthalmic chloramphenicol for preventing neonatal conjunctivitis in a trachoma endemic area in southern Mexico. British Journal of Ophthalmology. 2007;91:1430-4.
Chloramphenicol eye drops. MIMS Online. Accessed on 15 June 2019.
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Original version Date: 21/06/2019
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Author: NeoMed Consensus Group
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Current Version number: 1
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Current Version Date: 21/06/2019
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Risk Rating: Low
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Due for Review: 21/06/2024
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Approved by: DTC
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Approval Date: TBA
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