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Neonatal Intensive Care Drug Manual
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| bet | 120/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
For infusion take the baby’s weight in mls (3.0kg = 3ml) of undiluted Clonazepam solution (1000 microg/ml=1mg/ml) and make upto 25 ml with 5 % Dextrose or saline.
1 ml/hr.= 40 microg/kg/hr.
Stability :
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As per pharmacy.
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Storage :
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Room temperature
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Compatibility:
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Dextrose 2.5 %, 5% and 10 %. Sodium chloride 0.45 % and 0.9 %.
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Incompatibility :
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Do not mix with any other drugs or TPN
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Serum Levels :
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60-150 nmol/l. (Not very well defined). Not routinely performed.
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References:
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AMH Children’s Dosing Companion
RCH Paediatric Injectable Guidelines
IBM Micromedex
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Original version Date: 2014
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Author: ZK
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Current Version number: 2
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Current Version Date: 4/1/2021
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Risk Rating: Low
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Due for Review: 4/1/2026
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Approved by: DTC
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Approval Date: TBA
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Clonidine |
Revision Date : 15-12-2020
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Approved : TC, KOH
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Alert
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Hypertension may recur after cessation.
Neonatal abstinence syndrome may recur after cessation.
Evidence is insufficient to assess the efficacy and safety of clonidine for sedation and analgesia in term and preterm newborn infants receiving mechanical ventilation.
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Indication
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Sedation
Hypertension
Neonatal abstinence syndrome
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Action
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Clonidine is an α2-agonist used to produce reduction in blood pressure and sedation.
Compared with dexmedetomidine, clonidine has a lower selectivity for α2-receptors (α1:α2ratio of 1:1620 for dexmedetomidine versus 1:220 for clonidine). As central α2 effects are sedative, clonidine is less sedating than dexmedetomidine. [1]
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Drug type
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Sedative, hypnotic. Centrally acting α2-agonist.
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Trade name
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Catapres Ampoules
MZ Clonidine HCl Injection
APO-Clonidine Tablets
Catapres 100 Tablets
Catapres 150 Tablets
Oral solution or suspension: Compounded by pharmacy in-house (check which strength is stocked with Pharmacy Department).
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Presentation
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IV preparations:
150 microgram/mL ampoule
Oral preparations:
100 microgram/tablet, 150 microgram/tablet
Solution or suspension: Compounded by pharmacy in-house (check which strength is stocked with Pharmacy Department).
IV clonidine (ampoule) may be given orally either neat or diluted with water prior to administration to give a suitable dose volume.
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