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Neonatal Intensive Care Drug Manual
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| bet | 119/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Clonazepam
Revision Date : 04/01/2021
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Approved : ZK, KOH
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Indication :
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Seizures unresponsive to phenobarbitone and phenytoin.
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Dose :
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Loading dose 50-100 microg/kg over 2-5 minutes
Maintenance 25 microg/kg/dose
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Interval :
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8 hourly.
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Route :
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Loading dose IV
Maintenance orally.
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Total Daily Dose :
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0.1 mg/day (Tolerance may develop requiring higher dosing).
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Comments:
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Half-life varies, as for elimination maturity and plasma levels are not helpful in determining effect. Oral route of administration is preferred for maintenance. CNS depression, drowsiness, significant risk of hypoventilation/apnoea, hypotension and tachycardia are possible side effect. CAUTION in patients with impaired renal and hepatic function. Note that benzodiazepines tend to limit spread of electrical activity rather than completely suppress a focus entirely. Concurrent treatment with phenobarbitone or phenytoin has been shown to cause increased serum phenytoin levels and reduced clonazepam levels. Drug tolerance occurs if treatment is continued for any extended period of time. Dose must be gradually reduced when the drug is withdrawn to reduce the risk of rebound seizures.
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Supplied as :
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Parenteral Prep. vial 1 mg/ml.
Oral drops 2.5 mg/ml.
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Dilution :
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For loading doses and maintenance doses use water for injection and add 1ml of water to make 500 microg/ml solution.
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