Neonatal Intensive Care Drug Manual




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Aciclovir


Revision Date : April 2020

Approved : TC, KOH




Alert

High risk medicine.

Increased risk of renal impairment if there is concomitant use of other nephrotoxic drugs, pre-existing renal disease or dehydration.

Turbidity or crystallisation may occur even when mixed with compatible fluids. Discard preparation if this occurs before or during the infusion.

Highly alkaline and IV extravasation can cause severe tissue damage.



Indication

Treatment of neonatal herpes simplex virus (HSV) infection.

Treatment of varicella zoster virus (VZV) infection

HSV suppression following treatment to prevent CNS sequelae.


Action

Inhibits viral DNA synthesis when activated in infected cells.


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Neonatal Intensive Care Drug Manual

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