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Neonatal Intensive Care Drug Manual
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| bet | 16/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Known hypersensitivity to aciclovir, valganciclovir or any component of the product.
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Precautions
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Increased risk of renal impairment if there is concomitant use of other nephrotoxic drugs, pre-existing renal disease or dehydration. Administration interval may be lengthened to minimise renal effects. Refer to the renal adjustment dose in the dose adjustment section.
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Drug interactions
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Concurrent use with other nephrotoxic drugs may cause renal impairment (gentamicin, furosemide).
Concurrent use with ceftriaxone may cause renal impairment.
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Adverse reactions
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Neutropenia, thrombocytopenia may occur.
May cause
neurotoxicity with lethargy, tremor, and agitation.
transient renal impairment which is minimised by a slow administration rate.
transient rise in AST and total bilirubin.
phlebitis at IV injection site (highly alkaline solution). The solution can be made more dilute.
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Compatibility
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Fluids: sodium chloride 0.45%, sodium chloride 0.9%
Compatible via Y-site : Amikacin, ampicillin, anidulafungin, cefotaxime, ceftazidime, ceftriaxone, cefazolin, chloramphenicol, clindamycin, dexamethasone, doripenem, erythromycin, fluconazole, heparin sodium, hydrocortisone sodium succinate, imipenem–cilastatin, linezolid, lorazepam, magnesium sulfate, methylprednisolone sodium succinate, metronidazole, potassium chloride, ranitidine, remifentanil, sodium bicarbonate, tobramycin, trimethoprim-sulfamethoxazole, vancomycin, zidovudine
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Incompatibility
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Amino acid/glucose solution, glucose-containing solutions, adrenaline (epinephrine) hydrochloride, aztreonam, caffeine citrate, cefepime, ciprofloxacin, dobutamine, dopamine, esmolol, gentamicin, hydralazine, ketamine, labetalol, lidocaine (lignocaine), midazolam, pentamidine, phenylephrine, piperacillin–tazobactam (EDTA-free), potassium phosphate, sodium nitroprusside, sodium phosphate, ticarcillin–clavulanate, vecuronium, verapamil.
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Stability
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Diluted solutions should be used as soon as practicable, discard unused portion.
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Storage
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Store below 25°C. Do NOT refrigerate (may result in precipitation).
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Excipients
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Sodium hydroxide
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