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Suppression of HSV following treatment
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| bet | 15/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Suppression of HSV following treatment5
Oral 300 mg/m2/dose three times per day for 6 months.
Body Surface Area (BSA) calculation:
Dose adjustment
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Renal impairment (IV Treatment of HSV and VZV)
Creatinine concentration
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Dosage and Interval adjustment
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70–100 micromol/L
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20 mg/kg 12 hourly
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101–130 micromol/L
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20 mg/kg 24 hourly
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> 130 micromol/L and/or urine output < 1 mL/kg/hour
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10 mg/kg 24 hourly
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Maximum dose
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Total cumulative dose
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Route
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IV or Oral
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Preparation
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IV: If using Sandoz brand, reconstitute 250 mg vial with 10 mL or 500 mg with 20 mL of water for injection to obtain 25 mg/mL solution. If using DBL or Pfizer brand, vials contain 25 mg/mL solution.
Draw up 4 mL (100 mg) of aciclovir and add 16 mL sodium chloride 0.9% to make final volume 20 mL with a final concentration of 5 mg/mL.
Risk of phlebitis and extravasation increases at > 10 mg/mL. If a higher concentration is required, a solution of up to 25 mg/mL may be administered via a CENTRAL LINE ONLY.
Oral: Acyclo-V, Lovir, Ozvir and Zovirax brands come as dispersible tablets. Consider rounding if dose is close to half or quarter of a tablet. Disperse fraction of tablet in small quantity of water (e.g. 2 mL) and give dose immediately.
If this is not possible, disperse an entire tablet in a set quantity of water, ensure mixture is a uniform suspension, and draw up a fraction of this mixture and give immediately. If uniform suspension cannot be produced, contact pharmacy. Example: If dose is 30 mg, disperse 200 mg tablet in 10 mL of water to obtain 20 mg/mL mixture, and then give 1.5 mL.
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Administration
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IV Infusion: Infuse via syringe driver over 60 minutes.
Turbidity or crystallisation may occur even when mixed with compatible fluids. Discard preparation if this occurs before or during the infusion.
Oral: Dose can be given with feed.
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Monitoring
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Periodic full blood count, renal function, bilirubin, and hepatic transaminases.
IV site for phlebitis — prepare a more dilute infusion solution if phlebitis occurs.
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