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Neonatal Intensive Care Drug Manual
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| bet | 208/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Presentation
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IV:
10 mg/mL injection.
Oral:
20 mg/mL suspension compounded by pharmacy.
50 mg, 100 mg tablets.
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Dose
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Oral:
Starting dose: 1 mg/kg/dose 8 or 12 hourly. Increase by 1 mg/kg/dose as necessary to achieve maintenance of sinus rhythm up to the maximum dose.
IV:
2 mg/kg over at least 10 minutes.
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Dose adjustment
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No information.
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Maximum dose
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8 mg/kg/day
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Total cumulative dose
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Route
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Oral [preferred route] or IV
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Preparation (for IV administration)
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Draw up 1mL (10mg of flecainide) and add 9mL of glucose 5% to make a final volume of 10 mL with a concentration of 1mg/mL.
It can also be administered undiluted.
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Administration
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Oral:
Administer between milk feeds. Do not administer with milk. Milk decreases absorption of the drug.
IV:
Infusion over at least 10 minutes. Patient needs to be monitored very closely with the potential for an acute deterioration.
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Monitoring
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Initiate treatment in hospital with ECG monitoring in consultation with paediatric cardiologist.
When intravenous route is used, continuous ECG monitoring is mandatory.
Perform ECG when the dosage is increased – monitor QRS duration and dysrhythmia.
Therapeutic trough concentrations are not routinely required (200–1000 microgram/L).
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