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Neonatal Intensive Care Drug Manual
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| bet | 209/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Cardiogenic shock.
Hypersensitivity to flecainide.
Significant renal impairment (creatinine clearance < 50 mL/min).
Reduced left ventricular ejection fraction.
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Precautions
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Use with caution in patients with congenital heart disease or conduction system disease (right bundle branch block, with left hemiblock and without pacemaker; second- or third-degree atrioventricular block, without pacemaker; sick sinus syndrome [bradycardia-tachycardia syndrome]).
Milk decreases oral flecainide absorption. Consider decreasing oral dose or dose monitoring if change of milk diet.
Dosing adjustments are required in infants with renal impairment because 10% to 50% of a flecainide dose is excreted in the urine.
Use with caution in significant hepatic impairment.
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