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Neonatal Intensive Care Drug Manual
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| bet | 252/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Special comments
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Evidence
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Efficacy
Treatment of hypoglycaemia: The data are mainly derived from case series and case reports [10-13]. A single bolus dose of glucagon (200 microgram/kg) caused a rapid rise in hepatic glucose production rate in newborns with hypoglycaemia [12]. (LOE IV) Glucagon infusion (0.5–1 mg/day = 20–40 microgram/hour) resulted in a significant rise in blood glucose concentration within 4 hours of infusion in newborn infants irrespective of the cause of hypoglycaemia [13]. (LOE IV, GOR C). Glucose production in response to a glucagon 100 microgram/kg bolus was comparable in preterm, Appropriately Grown for Age and Small for Gestational Age infants [14]. (LOE IV). Glucagon infusion (20–40 microgram/hour) has been used to treat refractory hypoglycaemia in sick preterm infants (mean birth weight 1814 g and gestational age 32 weeks) [11]. (LOE IV)
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