Treatment of low-output heart failure associated with beta-blocker overdose: A case report of a preterm infant with low output heart failure after maternal labetalol use who responded to repeated use of intravenous glucagon 0.3 to 0.6 mg/kg [15] (LOE IV GOR C). This is consistent with doses in case reports of glucagon use for adult beta-blocker overdose. [16].
Safety
Hyponatraemia has been variably reported with glucagon infusion [13, 17, 18] although it may be explained by other factors including glucose infusion. (LOE IV GOR D) Thrombocytopenia has been reported [13, 17] although a case series found increasing platelet counts during infusion [11]. Erythema necrolyticum migrans (erythematosquamous skin lesions) has been reported with prolonged glucagon infusion [19, 20]. Glucagon has been reported to induce hypertension in patients with phaeochromocytoma [8, 10, 11]. Adverse cardiovascular events attributable to glucagon have not been reported in newborns.
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