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Neonatal Intensive Care Drug Manual
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| bet | 255/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Glycerol (Glycerine)
Revision Date :
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Approved : TC, KOH
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Indication
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Facilitation of passage of meconium. Constipation.
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Action
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Osmotic laxative that acts by increasing osmotic pressure in the gut; It also stimulates rectal, contraction. Onset may take 15–30 minutes.
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Drug Type
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Laxative
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Trade Name
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Petrus Glycerol Suppositories BP 0.7 g for Infants (glycerine)
Glycerol B.P. Liquid (Perrigo Australia)
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Presentation
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Suppositories – Petrus suppository infant size glycerol 0.7 g in a 1g suppository (also contains, gelatine and water),
Liquid – Glycerol B.P. 100 mL bottle. Contains 100% w/w glycerol.
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Dosage / Interval
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Glycerine suppository – sliver. Glycerol liquid – 0.2 mL of diluted 80% glycerol. *Refer to maximum daily dose section and evidence summary for alternate dose and, strength.
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Maximum Daily Dose
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Dose of 1 mL/kg of 1:4 diluted glycerol at 12–24 hour intervals has been used.
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Route
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PR
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Preparation/Dilution
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Glycerine suppository – cut a small sliver,
Glycerol liquid enema – Pharmacy to dilute 80 mL of 100% glycerol with 20 mL of sterile water to prepare a 80% v/v liquid glycerol.
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Administration
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Glycerine suppository – gently insert the sliver fully into the rectum.,
Glycerol liquid – draw 0.3 mL of diluted 80% glycerol into a 1 mL syringe. Attach Clot Catcher and, prime with the solution. Insert 1–2 cm of Clot Catcher through anus and administer 0.2 mL.
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Monitoring
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Stool Output
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