| Action
Proton pump inhibitor (PPI).
Drug Type
Proton pump inhibitor
Trade Name
Pantoprazole Sandoz 40 mg Powder for Injection (Sandoz), Somac Injection (Powder for injection) (Takeda Pharmaceuticals)
Presentation
IV: 40 mg/vial of pantoprazole in dry powder form.
PO: 2 mg/mL dispersion (compounded by Pharmacy) Australia Pharmaceutical Formulary and Handbook formula
Dosage / Interval
IV 0.5 mg/kg/dose 12 hourly
PO: 0.6–1.2 mg/kg/dose daily
Maximum daily dose
Route
IV, PO
Preparation/Dilution
A) IV infusion option: Add 10 mL of sodium chloride 0.9% to 40 mg powder for reconstitution to make a volume of 10 mL with a concentration of 4 mg/mL.
Draw up 1 mL (4 mg) and add 9 mL of sodium chloride 0.9% to make a final volume of 10 mL with a concentration of 0.4 mg/mL.
B) IV push option: Add 10 mL of sodium chloride 0.9% to 40 mg powder for reconstitution to make a volume of 10 mL with a concentration of 4 mg/mL
Administration
IV:
IV infusion — over 15 min
IV push — over at least 2 minutes.
PO: Give ½ hour before feed. Shake well before use.
Monitoring
Serum magnesium periodically during prolonged therapy.
Consider transaminase levels
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