| Contraindications
Liver disease.
Precautions
Short- and long-term safety data in infants are limited but there have been several safety concerns with long term usage in adults. Current FDA’s maximum recommended duration of therapy of PPIs is up to 8 weeks.
Drug Interactions
Concurrent use of ketoconazole may result in decreased ketoconazole exposure.
Concurrent use of ampicillin may result in loss of ampicillin efficacy.
Adverse Reactions
Limited data available, though appears well tolerated and to have few side effects. Uncommon reports of nausea, vomiting and skin rash.
Reported adverse events in adults:
Abdominal pain (3% ), diarrhea (4% ), flatulence (4% )
Neurologic: Headache (5% )
Atrophic gastritis, Clostridium difficile diarrhea
Haematological: Thrombocytopenia (less than 1% )
Immunological: Stevens-Johnson syndrome, toxic epidermal necrolysis
Musculoskeletal:, fracture of bone, osteoporosis-related hip fracture, rhabdomyolysis
Renal: Interstitial nephritis, acute
Compatibility
Fluids: Glucose 5%, glucose 10%, sodium chloride 0.9%.
Y site: Acetazolamide, alprostadil, aminophylline, amoxicillin sodium-clavulanate, amphotericin B phospholipid complex, amphotericin B liposomal, ampicillin, azithromycin, ceftriaxone, ganciclovir, imipenem-cilastatin, penicillin G, piperacillin, potassium chloride, theophylline, ticarcillin disodium, ticarcillin disodium-clavulanate, vasopressin, zidovudine.
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