Neonatal Intensive Care Drug Manual

Allergic disorders which suggest a predisposition to bronchospasm.

Right ventricular failure secondary to pulmonary hypertension.

Significant right ventricular hypertrophy.

Sinus bradycardia.

Second and third degree atrioventricular block or sick sinus syndrome unless a functioning pacemaker is present.

Shock, including cardiogenic and hypovolaemic shock.

Uncontrolled congestive heart failure.

Severe renal impairment.

Congenital or acquired long QT syndromes.

Hypersensitivity to sotalol hydrochloride or the excipients.

Anaesthesia that produces myocardial depression.

Atropine 10−30 microgram/kg/dose IV over 1 minute. Dose may be repeated every 10−15 minutes to achieve desired effect, with a maximum total dose of 40 microgram/kg.

No antiarrhythmic drug has been shown to reduce the incidence of sudden death in patients with supraventricular or asymptomatic ventricular arrhythmias. Sotalol is proarrhythmic in some situations and at higher doses.

Sotalol is renally excreted – use with caution in patients with renal impairment.