Neonatal Intensive Care Drug Manual




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Drug Interactions

Sotalol clearance is reduced by alcohol.
Other interactions include: Insulin and oral hypoglycaemics (hypo- and hyperglycaemia); calcium channel blockers (hypotension, bradycardia, heart failure); clonidine (hypertension); drugs that prolong the Qtc interval (quinolone antibiotics).

Sotalol interactions have been reported with other antiarrhythmics: Class IA agents, disopyramide and quinidine; class IB, tocainide, mexiletine and lignocaine; class IC, flecainide and propafenone; class III, amiodarone; and class IV antiarrhythmic agents. Concomitant use of sotalol with these agents and with other beta-blocking drugs is not recommended.


Concomitant use of sotalol and diuretics may increase the cardiotoxicity.


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Neonatal Intensive Care Drug Manual

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