Neonatal Intensive Care Drug Manual

• 
  Solprin® and Disprin® brands - contain no sodium. Aspro Clear® 300mg soluble tablets contain 6.5 mmol sodium per tablet – caution mother not to use Aspro Clear® brand after discharge.
  
• 
  G6PD deficient patients are at risk of haemolysis.
  
• 
  Give with feeds to reduce gastric irritation.
  
• 
  Not used as an analgesic or antipyretic in neonates, infants or children (due to the association with Reye’s syndrome).
  

Aspirin may cause gastrointestinal irritation including nausea, vomiting, abdominal pain, gastrointestinal upset, asymptomatic blood loss. If this occurs discussion should occur with the Cardiology team managing the patient as to whether aspirin can be ceased or addition of a H2 antagonist or proton pump inhibitor is required.

Dyspnoea, rhinitis, severe cutaneous adverse reactions (SCARs), skin reactions, gastrointestinal haemorrhage

Reye’s syndrome (more common with doses >40mg/kg/day), aplastic anaemia, erythema nodosum, granulocytosis, haemorrhagic vasculitis, intracranial haemorrhage, thrombocytopenia.

Bronchospasm, angioedema, urticaria and rhinitis have been precipitated by aspirin; there is cross-reactivity with other non-steroidal anti-inflammatory drugs (NSAIDs).

Give dose immediately and discard remaining solution.

1. 
   Pagliaro LA, Pagliaro AM editors. 2^nd Edition. Illinois: Problems in Paediatric Drug Therapy. 1987.
   
2. 
   Brustugun J, et al, Adjusting the dose in paediatric care: dispersing four different aspirin tablets and taking a portion, European Journal of Hospital Pharmacy, 2019.
   
3. 
   Australian Medicines Handbook [online] accessed 05/05/21