Neonatal Intensive Care Drug Manual

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Dosage/Interval
Pertussis (post-exposure prophylaxis or treatment) 10 mg/kg/dose daily orally or IV² for 5 days. Treatment of neonatal chlamydial conjunctivitis and pneumonitis 20 mg/kg/dose daily orally for 3 days. Eradication of Ureaplasma in preterm infants 20 mg/kg/dose daily IV for 3 days. Pneumonia due to Chlamydia or Mycoplasma pneumoniae >3 months of age Initial therapy or therapy for serious infection: 10 mg/kg/dose IV once a day on days 1 and 2, followed by oral therapy if needed. Step-down or Mild therapy: 10 mg/kg ORALLY on day 1, followed by 5 mg/kg once daily on days 2–5.
Route	Oral IV
Maximum Daily Dose	20 mg/kg
Preparation/Dilution	Oral: Add 9 mL of sterile water. Cap and shake well to produce 15 mL of suspension. Suspension expires 10 days after reconstitution. Write expiry date on bottle. IV: Add 4.8 mL of water for injection to the vial to make a concentration of 100 mg/mL solution. Shake until dissolved. Add 1 mL of reconstituted solution to 49 mL of sodium chloride 0.9% to make a concentration of 2 mg/mL and infuse over 1–3 hours. Maximum concentration for infusion is 2 mg/mL.

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