Indometatsin kuruk kiyomining gigroskopikligini aniklash natijalari
(Petri kosachasida olib borilgan tajribalar)
Vaqt, soat
|
Urganilgan nisbiy namliklar
|
58% (NaBr)
|
79% (NH4Cl)
|
90% (ZnSO4)
|
100% (N2O)
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
| |
3
|
5,066
|
5,124
|
1,14
|
5,025
|
5,236
|
4,20
|
5,104
|
5,365
|
5,11
|
5,043
|
5,610
|
11,24
| |
6
|
5,191
|
2,46
|
5,282
|
5,11
|
5,553
|
8,81
|
5,673
|
12,50
| |
9
|
5,254
|
3,71
|
5,341
|
6,30
|
5,650
|
10,70
|
5,754
|
11,11
| |
12
|
5,279
|
4,21
|
5,418
|
7,83
|
5,782
|
13,30
|
5,890
|
16,80
| |
24
|
5,338
|
5,38
|
5,475
|
8,97
|
5,942
|
16,41
|
5,981
|
18,61
| |
48
|
5,410
|
6,80
|
5,505
|
9,56
|
6,033
|
18,20
|
6,066
|
20,30
| |
72
|
5,429
|
7,18
|
5,537
|
10,20
|
6,153
|
20,55
|
6,209
|
23,12
| |
144
|
5,527
|
9,10
|
5,611
|
11,66
|
6,212
|
21,70
|
6,215
|
23,24
| |
216
|
5,597
|
10,48
|
5,614
|
11,72
|
6,218
|
21,82
|
6,221
|
23,36
|
Jadvaldagi natijalardan kurinib turibdiki, indometatsin kuruk kiyomining namlikni yutishi 100% nisbiy namlikda, 216 soat davomida maksimum 23,36% ni tashkil kilgan. SHu bilan birga 90%, 79% va 58% nisbiy namliklarda mos ravishda 21,82%, 11,72% va 10,48% ni tashkil kilgan.
Olingan natijalarni rasm kurinishida ifodalaydigan bulsak (2-rasm), 90 va 100% nisbiy namlikda olib borilgan tajriba natijalari 72 soatda maksimum natijani namoyon kilib, 216 soatgacha bulgan vakt oraligida deyarli uzgarmagan. Bundan xulsoa shuki, indometatsin kuru kiyomining maksimum darajada namlikni yutishi 72 soatda namoyon bulib, u urtacha 22,6% ni tashkil kilgan.
Shu bilan birga 58 va 79% nisbiy namliklarda olib borilgan natijalar indometatsin kuruk kiyomini maksimum darajada namlikni yutishi 144 soatda namoyon bulib, kolgan vaktda deyarli uzgarmagan. Natijada bu nisbiy namliklardagi tajriba natijalari indometatsin kururk kiyomini urtacha 11,1% gigroskopiklikka ega ekanligini kursatadi.
Olib borilgan tajriba natijalariga kura indometatsin kuruk kiyomi ishlatish davomida urtacha 79% gacha bulgan namlikda uzining turgunligini namoyot kila oladi deb xulosa kilishimiz mumkin.
Tashqi muxit namligini indometatsin quruq qiyomining sifatiga ta’sirini o‘rganish.
Tayyor dori turlariga qo‘yiladigan asosiy talabalardan biri ularni saqlanish jarayonida turg‘unligini ta’minlashdan iboratdir. Dori vositalarining turg‘unligiga tashqi muxitning qator omillari ta’sir qiladi. Nisbiy namlik, yorug‘lik kuchi, muxit xarorati va boqa omillar shular jumlasidandir. Bundan tashqari dorilarning turg‘unligi ularning tarkibiga kirgan yordamchi moddalarning turi va miqdoriga, tanlab olingan texnologik usulga, shuningdek ular joylashtirilgan idishlarga xam bog‘liqdir. SHu sababli yangi dori turlari texnologiyasi yaratilganda yoki mavjud bo‘lgan texnologiya takomillashtirilganda oxirigi xulosalar yaroqlilik muddati o‘rganilgandan so‘ng chiqarilishi lozim.
Yuqoridagi fikrlardan kelib chikib, tayyorlangan indometatsin kuruk kiyomining turgunligiga kadoklovchi idish va tashki muxit namligini ta’sirini urganishni maksadga muvofik deb topdik. Buning uchun tayyor kuruk kiyom 2-bobda keltirilgan idishlarga 10,0 g dan solinib kadoklandi va 58, 79, 90 va 100% nisbiy namlik saklagan eksikatorlarga joylashtirildi.
Eksikatorlarga joylashtirilgan kadoklangan indometatsin kuruk kiyomining namlikni yutishi xar 3 soat davomida 3 kun mobaynida urganib borildi. Tajriba natijalari jadvalda keltirilgan.
Indometatsin quruq qiyomining turg’unligiga qadoqlovchi idish va tashqi muxit namligining ta’sirini o’rganish natijalari
(Burama plastmassa qopqoqli TST 64-2087-81 qo’ng’ir rangli shisha idishga TST 64-2-71-80 qadoqlangan quruq qiyom)
Vaqt, soat
|
O’rganilgan nisbiy namliklar
|
58% (NaBr)
|
79% (NH4Cl)
|
90% (ZnSO4)
|
100% (N2O)
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
| |
3
|
10,111
|
-
|
-
|
10,061
|
-
|
-
|
10,019
|
-
|
-
|
10,021
|
-
|
-
| |
6
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
| |
9
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
| |
12
|
-
|
-
|
-
|
-
|
-
|
-
|
10,126
|
1,05
| |
24
|
-
|
-
|
-
|
-
|
10,127
|
1,08
|
10,142
|
1,21
| |
48
|
-
|
-
|
10,082
|
0,21
|
10,150
|
1,31
|
10,164
|
1,43
| |
72
|
10,146
|
0,35
|
10,105
|
0,44
|
10,174
|
1,55
|
10,189
|
1,68
| |
144
|
10,165
|
0,54
|
10,129
|
0,68
|
10,186
|
1,67
|
10,204
|
1,83
| |
216
|
10,173
|
0,61
|
10,144
|
0,83
|
10,201
|
1,82
|
10,231
|
2,10
|
Indometatsin quruq qiyomining turg’unligiga qadoqlovchi idish va tashqi muxit namligining ta’sirini o’rganish natijalari
(Polietilendan - DST 16338-85E tayyorlangan idish STPUz 2313-01-95)
Vakt, soat
|
O’rganilgan nisbiy namliklar
|
58% (NaBr)
|
79% (NH4Cl)
|
90% (ZnSO4)
|
100% (N2O)
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
|
m1
|
m2
|
%
| |
3
|
10,106
|
-
|
-
|
10,008
|
-
|
-
|
9,996
|
-
|
-
|
9,998
|
10,101
|
1,03
| |
6
|
-
|
-
|
-
|
-
|
10,101
|
1,05
|
10,323
|
3,25
| |
9
|
10,116
|
0,1
|
10,322
|
3,14
|
10,208
|
2,12
|
10,523
|
5,25
| |
12
|
10,224
|
1,17
|
10,410
|
4,02
|
10,361
|
3,65
|
10,614
|
6,16
| |
24
|
10,346
|
2,37
|
10,580
|
5,71
|
10,436
|
4,4
|
10,621
|
6,23
| |
48
|
10,435
|
3,25
|
10,612
|
6,03
|
10,541
|
5,45
|
10,632
|
6,34
| |
72
|
10,521
|
4,11
|
10,620
|
6,11
|
10,621
|
6,25
|
10,641
|
6,43
| |
144
|
10,616
|
5,05
|
10,623
|
6,14
|
10,629
|
6,33
|
10,644
|
6,46
| |
216
|
10,622
|
5,10
|
10,628
|
6,19
|
10,631
|
6,35
|
10,645
|
6,47
|
|
