Neonatal Intensive Care Drug Manual




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Chronic hypertension: Recommend to use at lower doses (2–10 µg/kg/day) in 3 or 4 divided doses) in combination with other antihypertensive agents rather than at higher dose as a single agent.

References

  1. Bada HS, Sithisarn T, Gibson J, Garlitz K, Caldwell R, Capilouto G, Li Y, Leggas M, Breheny P. Morphine versus clonidine for neonatal abstinence syndrome. Pediatrics. 2015;135:e383-91.

  2. Hunseler C, Balling G, Rohlig C, Blickheuser R, Trieschmann U, Lieser U, Dohna-Schwake C, Gebauer C, Moller O, Hering F, Hoehn T, Schubert S, Hentschel R, Huth RG, Muller A, Muller C, Wassmer G, Hahn M, Harnischmacher U, Behr J, Roth B, Clonidine Study G. Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial. Pediatr Crit Care Med. 2014;15:511-22.

  3. Binda Ki Muaka P, Proesmans W. Intravenous clonidine in severe childhood hypertension. Acta Paediatrica Belgica. 1980;32:247-51.

  4. Batisky DL. Neonatal Hypertension. Clinics in Perinatology. 2014;41:529-42.

  5. Dionne JM, Abitbol CL, Flynn JT. Hypertension in infancy: Diagnosis, management and outcome. Pediatric Nephrology. 2012;27:17-32.

  6. Verlhac C, Lannoy D, Bourdon F, Titecat M, Frealle E, Nassar C, Berneron C, Odou P. Physicochemical and Microbiological Stability of a New Oral Clonidine Solution for Paediatric Use. Pharmaceutical Technology in Hospital Pharmacy. 2018;3:79-90.

  7. Romantsik O, Calevo MG, Norman E, Bruschettini M. Clonidine for sedation and analgesia for neonates receiving mechanical ventilation. Cochrane Database of Systematic Reviews. 2017.

  8. Hayden JC, Breatnach C, Doherty DR, Healy M, Howlett MM, Gallagher PJ, Cousins G. Efficacy of alpha2-Agonists for Sedation in Pediatric Critical Care: A Systematic Review. Pediatr Crit Care Med. 2016;17:e66-75.

  9. Lambert P, Cyna AM, Knight N, Middleton P. Clonidine premedication for postoperative analgesia in children. Cochrane Database of Systematic Reviews. 2014.

  10. Zhu A, Benzon HA, Anderson TA. Evidence for the Efficacy of Systemic Opioid-Sparing Analgesics in Pediatric Surgical Populations: A Systematic Review. Anesth Analg. 2017;125:1569-87.

  11. Disher T, Gullickson C, Singh B, Cameron C, Boulos L, Beaubien L, Campbell-Yeo M. Pharmacological Treatments for Neonatal Abstinence Syndrome: A Systematic Review and Network Meta-analysis. JAMA Pediatr. 2019;173:234-43.

  12. Agthe AG, Kim GR, Mathias KB, Hendrix CW, Chavez-Valdez R, Jansson L, Lewis TR, Yaster M, Gauda EB. Clonidine as an adjunct therapy to opioids for neonatal abstinence syndrome: a randomized, controlled trial. Pediatrics. 2009;123:e849-56.

  13. Surran B, Visintainer P, Chamberlain S, Kopcza K, Shah B, Singh R. Efficacy of clonidine versus phenobarbital in reducing neonatal morphine sulfate therapy days for neonatal abstinence syndrome. A prospective randomized clinical trial. J Perinatol. 2013;33:954-9.

  14. Ghazanfarpour M, Najafi MN, Roozbeh N, Mashhadi ME, Keramat-Roudi A, Megarbane B, Tsatsakis A, Moghaddam MMM, Rezaee R. Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials. Daru. 2019;27:423-31.

  15. Dhull RS, Baracco R, Jain A, Mattoo TK. Pharmacologic Treatment of Pediatric Hypertension. Current Hypertension Reports. 2016;18 (4) (no pagination).

  16. Wuhl E, Trivelli A, Picca S, Litwin M, Peco-Antic A, Zurowska A, Testa S, Jankauskiene A, Emre S, Caldas-Afonso A, Anarat A, Niaudet P, Mir S, Bakkaloglu A, Enke B, Montini G, Wingen AM, Sallay P, Jeck N, Berg U, Caliskan S, Wygoda S, Hohbach-Hohenfellner K, Dusek J, Urasinski T, Arbeiter K, Neuhaus T, Gellermann J, Drozdz D, Fischbach M, Moller K, Wigger M, Peruzzi L, Mehls O, Schaefer F. Strict blood-pressure control and progression of renal failure in children. New England Journal of Medicine. 2009;361:1639-50.

  17. Deitrick J, Stevenson K, Nguyen D, Sessions W, Linga V, Vasylyeva T. Hypertension secondary to renal hypoplasia presenting as acute heart failure in a newborn. Clin. 2019;25:10.

  18. Veenhoven RH, Vande Walle JG, Donckerwolcke RA, Wit JM, Griffiven AW, Derkx FH, Schalekamp MA. A neonate with idiopathic hyperaldosteronism. Pediatr Nephrol. 1991;5:680-4.

  19. Potts AL, Larsson P, Eksborg S, Warman G, Lonnqvist PA, Anderson BJ. Clonidine disposition in children; a population analysis. Paediatr Anaesth. 2007;17:924-33.

  20. Sheng Y, Standing JF. Pharmacokinetic reason for negative results of clonidine sedation in long-term-ventilated neonates and infants. Pediatr Crit Care Med. 2015;16:92-3.

  21. Larsson P, Nordlinder A, Bergendahl HT, Lonnqvist PA, Eksborg S, Almenrader N, Anderson BJ. Oral bioavailability of clonidine in children. Paediatr Anaesth. 2011;21:335-40.

  22. https://www.micromedexsolutions.com.acs.hcn.com.au/micromedex2/ accessed 14/02/2020

  23. https://www.mimsonline.com.au.acs.hcn.com.au/ accessed 14/02/2020

https://amhonline.amh.net.au.acs.hcn.com.au/search?q=clonidine accessed 14/02/2020




Original version Date: 28/5/2020

Author: NeoMed Consensus Group

Current Version number:  2

Current Version Date:  15/12/2020

Risk Rating: Medium

Due for Review:  15/12/2025

Approved by: DTC

Approval Date: TBA


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Neonatal Intensive Care Drug Manual

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