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Neonatal Intensive Care Drug Manual
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| bet | 36/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Hyperbilirubinaemia: Trials of albumin infusion pre-exchange transfusion for severe neonatal jaundice reported use of albumin 20% (see albumin 20% formulary).
Polycythaemia: A single RCT [11] compared isotonic saline versus 5% albumin in 102 term infants as replacement fluid in partial exchange transfusion (PET) for the treatment of neonatal polycythaemia. PET with either resulted in a decline in haematocrit up to 24 hours after PET with no difference between groups and no adverse event reported. A systematic review [12] of PET for polycythaemia, most RCTs compared plasma preparations to no treatment. The review reported there are no proven clinically significant short or long-term benefits of PET in polycythaemic newborn infants who are clinically well or who have minor symptoms related to hyperviscosity, and there may be an increased risk of NEC. Conclusion: Albumin solutions cannot be recommended as the preferred method of PET for polycythaemia. [LOE II GOR C]
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