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Neonatal Intensive Care Drug Manual
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| bet | 34/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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History of allergy to albumin.
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Precautions
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Cardiac failure, pulmonary oedema or severe anaemia.
The sodium concentration in this product is 140 mmol/L. This should be noted when the product is used in patients requiring sodium restriction.
Administration of albumin can aggravate myocardial depression in patients with shock.
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Drug Interactions
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Hypotension has been reported in patients given albumin who are on angiotensin converting enzyme (ACE) inhibitors. The addition of other medicines to Albumex® 4 has not been evaluated.
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Adverse Reactions
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Allergic reactions.
Possible harms associated with albumin infusion in neonates include fluid overload (pulmonary oedema, impaired gas exchange, worsening oxygenation, chronic lung disease, patent ductus arteriosus, myocardial dysfunction especially for infants with birth asphyxia), neurological injury (cerebral oedema, intraventricular haemorrhage due to rapid bolus administration), salt loading and fluid retention.
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Compatibility
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Glucose 5% and 10%, glucose-sodium chloride combination. [2]
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Incompatibility
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Albumex® 4 should not be mixed with protein hydrolysates, amino acid solutions, solutions containing alcohol or solutions containing drugs that bind to albumin (e.g. calcium channel blockers, antibiotics and benzodiazepines).
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Stability
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Storage
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Store below 30°C (Do not freeze). Protect from light. If the product has been stored in the refrigerator it should be allowed to reach room temperature before administration. Do not use if the solution has been frozen.
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