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Neonatal Intensive Care Drug Manual
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| bet | 39/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Albumin 20%
Revision Date : 27/04/2021
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Approved : TC,KOH
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Alert
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Albumex® 20 is normally clear or slightly opalescent. If it appears to be turbid it must not be used and the bottle should be returned unopened to the Australian Red Cross Blood Service.
Albumin 20% must not be used as the initial resuscitating fluid in hypotensive infants.
If the product has been stored in the refrigerator it should be allowed to reach room temperature before administration.
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Indication
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Hypoalbuminaemia
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Action
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Albumin is involved in the maintenance of colloid osmotic pressure, binding and transport of plasma compounds (bilirubin, bile acids, long-chain fatty acids, thyroxin, vitamin D, calcium, magnesium, copper, zinc), renders some potential toxins harmless, is a carrier of nitric oxide and affects pharmacokinetics of many drugs. Albumin 20% is hyper-oncotic but hypo-osmotic (130 mOsm/kg) compared to human serum with a pH 6.7 to 7.3. The half-life of albumin is about 19 days.
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Drug Type
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Plasma product, manufactured from human plasma collected by the Australian Red Cross Blood Service.
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Trade Name
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Albumex® 20
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Presentation
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Albumex® 20 – 10 mL (2 g albumin) and 100 mL (20 g albumin) bottles.
Each bottle contains Human Albumin 200 g/L and sodium 48 to 100 mmol/L.
Albumex® 20 contains trace amounts of aluminium (≤200 micrograms/L).
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