Neonatal Intensive Care Drug Manual

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Contraindications
History of allergy to albumin.
Precautions	Cardiac failure, pulmonary oedema or severe anaemia. The sodium concentration in this product varies between 48 and 100 mmol/L. This should be noted when the product is used in patients requiring sodium restriction. Administration of albumin can aggravate myocardial depression in patients with shock.
Drug Interactions	Hypotension has been reported in patients given albumin who are on angiotensin converting enzyme (ACE) inhibitors. The addition of other medicines to Albumex® 20 has not been evaluated.
Adverse Reactions	Allergic reactions. Possible harms associated with albumin infusion in neonates include fluid overload (pulmonary oedema, impaired gas exchange, worsening oxygenation, chronic lung disease, patent ductus arteriosus, myocardial dysfunction especially for infants with birth asphyxia), neurological injury (cerebral oedema, intraventricular haemorrhage due to rapid bolus administration), salt loading and fluid retention.
Compatibility	Glucose 5% and 10%, glucose-sodium chloride combination.¹⁸
Incompatibility	Albumex® 20 should not be mixed with protein hydrolysates, amino acid solutions, solutions containing alcohol or solutions containing drugs that bind to albumin (e.g. calcium channel blockers, antibiotics and benzodiazepines).
Stability
Storage	10 mL: Store at 2°C to 8°C (Refrigerate. Do not freeze). 100 mL: Store below 30°C (Do not freeze). Protect from light.

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