• Drug Interactions None known. Adverse Reactions
  • Compatibility
  • Incompatibility
    		•

    Neonatal Intensive Care Drug Manual




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    Renal impairment: Significantly increases half-life of milrinone. A reduction in the infusion rate in patients with renal impairment to prevent drug accumulation is advised.

    Patient recovery: Improvement in cardiac output with resultant diuresis may necessitate a reduction in the dose of diuretic. Potassium loss due to excessive diuresis may predispose digitalised patients to arrhythmias.


    Drug Interactions

    None known.

    Adverse Reactions


    Ventricular arrhythmias in cardiac patients.

    Patent ductus arteriosus.

    May cause hypotension.


    Compatibility


    Fluids: Glucose 5%, sodium chloride 0.9%.
    Y-site: Amino acid solutions, aciclovir, adrenaline (epinephrine) hydrochloride, amikacin,,

    amiodarone, atracurium, bivalirudin, calcium chloride, calcium gluconate, caspofungin, cefazolin, cefepime, cefotaxime, dexmedetomidine, digoxin, dobutamine, dopamine, doripenem, fentanyl, glyceryl trinitrate, heparin sodium, insulin (short-acting), magnesium sulfate heptahydrate, meropenem, metoprolol, midazolam, morphine sulfate, pentahydrate, noradrenaline, (norepinephrine), pancuronium, potassium chloride, ranitidine, rocuronium, sodium nitroprusside, vancomycin, vecuronium, verapamil.

    Incompatibility



    Fluids: Sodium bicarbonate.
    Y-site: Bumetanide, esmolol, furosemide (frusemide), imipenem + cilastatin, ondansetron.


    Stability

    Primacore: If storage is necessary, diluted solution may be stored below 30°C and use within 24 Hours.

    Milrinone GH: If storage is necessary, diluted solution may be stored at 2-8°C and use within 24 Hours. Milrinone-Baxter: Diluted solution should be used immediately or as soon as practical to reduce microbiological hazard.

    Storage

    Primacor and Milrinone Baxter: Store below 30°C. Do not freeze.

    Milrinone GH: Store below 25°C. Do not freeze. Protect from light.

    Excipients

    Primacore, Milrinone GH, Milrinone-Baxter: Glucose (monohydrate or anhydrous), lactic acid or sodium hydroxide (for pH adjustment), and water for injections.



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    Neonatal Intensive Care Drug Manual

    Download 1,5 Mb.