Term Infants
Infusion strength
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Prescribed amount
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1 mL/hour = 0.33 microgram/kg/minute
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1 mL/hour = 0.33 microgram/kg/minute
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Draw up 1mL/kg (1000 microgram/kg of milrinone) and add sodium chloride 0.9% or glucose 5% to make a final volume of 50mL. Infusing at a rate of 1mL/hour = 0.33 microgram/kg/minute
OPTIONAL- Give a loading dose of 3.75 mL (75 microgram/kg) over 1 hour (Note: risk of hypotension with loading dose).
For term infants ─ if loading is not given, higher maintenance infusion may be required to reach the steady drug range of 0.5−0.75 microgram/kg/minute.
Pre-term infants and renal impairment,
Infusion strength
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Prescribed amount
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1 mL/hour = 0.2 microgram/kg/minute
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0.6 mL/kg milrinone and make up to 50mL
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Draw up 0.6mL/kg (600 microgram/kg of milrinone) and add sodium chloride 0.9% or glucose 5% to make a final volume of 50mL. Infusing 1mL/hour = 0.2microgram/kg/minute.
OPTIONAL - Give a loading dose of 3.75 mL (45 microgram/kg) over 1 hour (Note: risk of hypotension with loading dose).
For preterm infants ─ if loading dose is not given, titrate the maximal infusion rate to 0.5 microgram/kg/minute if required. Avoid prolonged infusion > 0.2 microgram/kg/minute in very preterm infants
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