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Original version Date: 2014
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| bet | 408/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Original version Date: 2014
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Author: AK, JD
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Current Version number: 2.0
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Current Version Date: 24/12/2020
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Risk Rating: Medium
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Due for Review: 24/12/2025
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Approval by: DTC
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Approval Date: TBA
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Omeprazole |
Revision Date :19/07/2018
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Approved: TC, KOH
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Alert
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Short- and long-term safety data in infants are limited. There have been several safety concerns with long-term usage in adults.
The bioavailability of the in-house pharmacy suspension made from the contents of the capsule may be less (up to 50% less) than that of the capsule itself. Dose may need to be adjusted if no clinical response.
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Indication
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Treatment of gastroesophageal reflux disease (GORD).
Prophylaxis in congenital tracheoesophageal fistula and oesophageal atresia (role unclear).
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Action
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Omeprazole is a proton pump inhibitor (PPI).
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Drug Type
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Proton Pump Inhibitor.
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Trade Name
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APO-Omeprazole Capsules (Apotex) 20 mg
Omeprazole Sandoz IV Powder for injection (Sandoz]) 40 mg.
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Presentation
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20 mg/capsule; 10 mg tablets; 20 mg tablets.
Oral suspension of 2 mg/mL prepared in pharmacy.
Omeprazole Sandoz IV Powder for injection 40 mg.
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Dosage / Interval
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PO: 0.5–1.5 mg/kg/dose daily
IV: 0.5 mg/kg/dose daily
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Maximum daily dose
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1.5 mg/kg/dose
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Route
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PO, IV
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Preparation/Dilution
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PO: In-house pharmacy can prepare a 2 mg/mL suspension using these capsules as follows: Disperse 100 mg omeprazole in 50 mL of 8.4% sodium bicarbonate solution.
1 mL of omeprazole suspension contains 2 mg omeprazole, 1 mmol sodium and 1 mmol bicarbonate.
IV: Add 10 mL of sodium chloride 0.9% to 40 mg powder for reconstitution to make a concentration of 4 mg/mL. Draw up 1 mL (4 mg) and add 9 mL of sodium chloride 0.9% to make a final volume of 10 mL with a concentration of 0.4 mg/mL.
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Administration
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PO: Administer prior to meals.
IV: Infuse over 30 minutes.
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Monitoring
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Serum magnesium in patients on prolonged therapy or who use digoxin or drugs that may cause hypomagnesaemia (e.g. diuretics) concomitantly.20-21
Serum vitamin B12 — every 1 to 2 years in patients on prolonged therapy.20-21
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