IV injection dose less than 5 microgram
Draw up 20 microgram and make up to 1 mL total volume with 0.9% sodium chloride
Concentration now equal to 2 microgram/0.1 mL
Infuse over 15-30 minutes
IV injection dose 5 microgram or more
Use undiluted
Infuse over 15-30 minutes
In emergency situations, inject undiluted over 3 minutes
SUBCUTANEOUS
Dose less than 5 microgram
Draw up 20 microgram and make up to 1 mL total volume with 0.9% sodium chloride
Concentration now equal to 2 microgram/0.1 mL
Dose 5 microgram or more
Use undiluted
Allow solution to reach room temperature before administration (minimises discomfort)
Subcutaneous injection into the anterolateral thigh (use a subcutaneous delivery device for longer term administration)
Rotate injection sites
Stability :
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Ampoules: until expiry date on label
Infusion solution is stable for 24 hours at room temperature (25˚C) in sodium chloride 0.9%
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Storage :
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Ampoules: Refrigerate between 2-8 degree celsius. Protect from light.
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Compatability:
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5% Dextrose, 0.9% NaCl (preferred infusion fluid), Heparin, Potassium and TPN via a Y site.
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Incompatibility :
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Insulin, Pantoprazole
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Serum Levels :
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Not required
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References
1. British National Formulary for Children (BNFC) online. Octreotide. [Internet]: Royal Pharmaceutical Society; [cited 24-12-2020]. Available from: https://www.medicinescomplete.com.
2. IBM Micromedex®Neofax®. Octreotide. In: IBM Micromedex® NeoFax®/Pediatrics (electronic version). [Internet]. IBM Watson Health, Greenwood Village, Colorado, USA. J [cited 24-12-2020]. Available from: http://neofax.micromedexsolutions.com/neofax.
3. Australian Medicines Handbook Children's Dosing Companion. Octreotide. [Internet]. Adelaide: Australian Medicines Hanbook Pty Ltd; [cited 24-12-2020]. Available from: https://amhonline.amh.net.au.
4. Ainsworth S. Neonatal Forumlary: Drug Use in Pregnancy and the First Year of Life. 7th ed. West Sussex: Wiley Blackwell; 2015.
5. Australian Injectable Drugs Handbook. Nicolette Burridge, Keli Symons, editors. Octreotide. 7th ed. [Internet]. New South Wales: Society of Hospital Pharmacists of Australia (SHPA); [cited 24-12-2020]. Available from: https://aidh.hcn.com.au.
6. Das A, Shah PS. Octreotide for the treatment of chylothorax in neonates. Cochrane Database of Systematic Reviews. 2010; Issue 9. Art. No.: CD006388 DOI:10.1002/14651858.CD006388.pub2
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