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Neonatal Intensive Care Drug Manual
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| bet | 89/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Caution in patients with renal or cardiac impairment.
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Precautions
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Do not give calcium solutions and sodium bicarbonate simultaneously by the same route to avoid precipitation.
Ensure IV calcium is administered at a different time to phosphates, carbonates, sulfates or tartrates (precipitates can occur).
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Drug Interactions
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Ceftriaxone (may cause insoluble precipitates and can be fatal), digoxin (serious risk of arrhythmia and cardiovascular collapse), thiazide diuretics (increased risk of hypercalcaemia), ketoconazole (decreased ketoconazole effect).
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Adverse Reactions
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Rapid administration is associated with bradycardia or asystole.
Rash, pain, burning at injection site, cutaneous necrosis with extravasation (give via central line unless otherwise instructed by a neonatologist)
Nephrolithiasis with long-term use.
Gastric irritation, diarrhoea and NEC have occurred during oral therapy with hyperosmolar preparations (must be diluted if used orally. See separate guideline Calcium - ORAL)
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Compatibility
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Fluids: Glucose 5%, glucose 10%, Hartmann’s, sodium chloride 0.9%
Y-site: Amifostine, amiodarone, aztreonam, bivalirudin, ceftaroline fosamil, cisatracurium, dexmedetomidine, doripenem, filgrastim, granisetron, heparin sodium, hydrocortisone sodium succinate, labetalol, linezolid, midazolam, milrinone, piperacillin-tazobactam (EDTA-free), potassium chloride, remifentanil.
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