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AmBisome (amphotericin B) liposome for injection
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| bet | 66/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Presentation
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Amphotericin BP equivalent to 50 mg of amphotericin B vial.5
Premade syringe by local pharmacy
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Dose
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3 mg/kg/dose daily.6
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Dose adjustment
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To be updated.
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Maximum dose
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7 mg/kg/day.7
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Total cumulative dose
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Route
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IV
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Preparation
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Add 12 mL of water for injection to 50 mg vial to make a 4 mg/mL solution. Shake vigorously for at least 30 seconds to disperse completely.
FURTHER DILUTE
Use the 5 micrometre filter supplied, draw up 4 mL (16 mg of amphotericin B liposomal) of the above solution and add 12 mL of glucose 5% to make a final volume of 16mL with a final concentration of 1mg/mL.3,5
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Administration
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IV line must be flushed with 5% glucose before and after the dose.
IV infusion over 60 minutes.3
In-line filters must have a port diameter of at least 1 micrometre.
Do not mix with any medications.
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Monitoring
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Urine output.
Full blood count for anaemia and thrombocytopenia
Renal function electrolytes for hypokalaemia
Liver function.
Serum concentrations of concomitant nephrotoxic drugs.
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