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Neonatal Intensive Care Drug Manual
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| bet | 67/654 | | Sana | 03.01.2022 | | Hajmi | 1,5 Mb. | | #14803 |
Contraindications
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Known hypersensitivity to amphotericin B.
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Precautions
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Administer under close clinical supervision during the initial dosing. Anaphylaxis and respiratory distress have been reported in adults (though not in neonates).
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Drug interactions
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Increased risk of nephrotoxicity if used concurrently with other nephrotoxic drugs (even though the liposomal preparation is safer than conventional amphotericin B in this regard) e.g. aminoglycosides, vancomycin. Monitor renal function and relevant drug concentrations closely.
Adequate clinical studies of the use of the combination of flucytosine with AmBisome have not been conducted. Whilst synergy between flucytosine and amphotericin has been reported, amphotericin B may enhance the toxicity of flucytosine by increasing its cellular uptake and impeding its renal excretion.3
Corticosteroids and diuretics: May enhance the hypokalaemic effect of amphotericin B.
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