• Confusion between these products has led to fatal overdose as well as subtherapeutic dosing. 1
  • Drug type Polyene antifungal Trade name
    		•

    Amphotericin B- Liposomal




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    Amphotericin B- Liposomal


    Revision Date : 16-11-2020

    Approved : TC, KOH




    Alert

    Antimicrobial Stewardship Team has listed this drug as Restricted.

    Clinicians should liaise with local ID specialists when treating systemic fungal infections.

    Available in 4 forms: Amphotericin B -conventional, Amphotericin B - liposomal, Amphotericin B (phospho) lipid complex and Amphotericin B colloidal dispersion also known as Amphotericin B Cholesteryl Sulfate Complex.

    Confusion between these products has led to fatal overdose as well as subtherapeutic dosing.1


    Indication

    Treatment of invasive fungal infections by susceptible fungi including Candida spp., Aspergillus spp. and Cryptococcus species.2,3 Candida lusitaniae and A. terreus are resistant.

    Action

    Fungicidal agent which works by binding with a cytoplasmic membrane ergosterol on the organism’s surface causing cell death by increasing cell membrane permeability.4

    Drug type

    Polyene antifungal

    Trade name


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