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Volume 1 Issue 1
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January 2024
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ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES
“Innovative World” Scientific Research Support Center www.inno-world.uz
A and group C in total and partial recovery, with group C demonstrating full
improvement of these abilities [19].
Study 5
Regarding HSV quantification, a significant reduction was observed in all study
groups (group A: topical antiviral therapy (TAT); group B: antimicrobial
photodynamic therapy (aPDT); group C: combination therapy with TAT + aPDT)
during each follow-up. Group C exhibited a statistically
higher reduction than
both group A and group B. Pain scores significantly decreased in all groups, with
Group C reporting a statistically higher decrease compared to both Group A and
Group B. In relation to biomarkers, both IL-6 and TNF-α showed a statistically
significant reduction after 2 weeks. Group C demonstrated
a statistically higher
reduction both between groups and within groups at every time point [20].
Results of syntheses
Acyclovir (ACV) was employed either in combination or alone in four of the
included studies (1, 2, 3, and 5). In combination, ACV was paired with honey (1),
fluids and analgesics (3), and antimicrobial photodynamic therapy (aPDT) (5).
When ACV was used alone (study 2), it significantly shortened the duration of
all clinical manifestations and the infectivity of affected
children compared to
placebo.
The combined use of honey and oral ACV (study 1) yielded more favorable
outcomes, including the earlier disappearance of herpetic oral lesions, drooling,
and eating difficulty;
lower pain scores; better eating and drinking ability; and
significantly less need for analgesics, compared to acyclovir alone in children with
primary herpetic gingivostomatitis (PHGS).
ACV therapy in conjunction with aPDT (study 5) contributed to the reduction of
pain scores and pro-inflammatory cytokine levels in herpetic gingivostomatitis
among children.
One study (4) utilized non-alcoholic chlorhexidine
alone or in combination
with other substances, such as hyaluronic acid or verbascoside and sodium
hyaluronate (Mucosyte®).
When non-alcoholic chlorhexidine was used in combination with Mucosyte®, a
significant improvement in pain scoring and lesion severity was noted compared
to non-alcoholic chlorhexidine alone and non-alcoholic chlorhexidine plus
hyaluronic acid, respectively.
Study 3 reported the use of fluids and analgesics alone
or in combination with
viscous lidocaine and a mixture of maalox and diphenhydramine, but the authors
did not provide any comparison among the described therapies.
Finally, the studies (4 and 5) that included adolescent patients involved topical
therapies and/or non-pharmacological treatments, while the studies (1, 2, and 3)
that focused on pediatric subjects primarily employed ACV, except for study 3,
which reported mixed therapies.
