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Volume 1 Issue 1
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January 2024
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ORIENTAL JOURNAL OF MEDICINE AND NATURAL SCIENCES
“Innovative World” Scientific Research Support Center www.inno-world.uz
Introduction
Herpes viruses, members
of the Herpesviridae family, are double-stranded
DNA viruses with a distinct four-layered structure
comprising a core housing a
large, double-stranded DNA genome, an icosapentahedral capsid, an amorphous
protein coat called the tegument, and a lipid
bilayer envelope bearing
glycoproteins [1, 2]. There are over 200 members in this family, and eight of
them, including herpes simplex virus (HSV) 1 and 2, varicella-zoster virus (VZV),
Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6),
human herpesvirus 7 (HHV-7), and Kaposi’s sarcoma virus (KSHV), are capable of
infecting humans [2].
Herpesviruses are known for
infecting various cell types, establishing a
reactivatable latent infection in a specific tissue or cell type. Periodically,
the virus
reactivates, leading to clinical recurrence of the disease, triggered by factors such
as heat, cold, trauma, fever, stress, and changes in the host’s immune defense
status [1].
HSV-1 is a prominent pathogen responsible
for global infections, transmitted
through direct contact with lesions or biological fluids like saliva and genital
fluids. The majority of people come into contact with HSV-1 in their lifetime,
harboring the virus in a latent form. According to the World Health Organization
